The amount of hormones needed for a male to female sex change varies from person to person and depends on many factors, including genetics and age. A healthcare provider specializing in transgender care can guide you through the process.
The goal of hormone therapy is to reduce testosterone levels to a normal female range (30–100 ng/dl) while avoiding supra-physiological levels of estradiol (<200 pg/ml). A common hormone regimen for transgender women includes:
Estrogen
Estradiol is the preferred estrogen because it most closely resembles the hormone produced by the ovaries. Doses can range from 2–6 mg/day orally, or 5–20 mg of estradiol valerate intramuscularly every two weeks.
Anti-androgens
These suppress the production of androgens, reducing masculine characteristics. Common anti-androgens include cyproterone and spironolactone.
Progesterone
Some clinicians may add progesterone to the regimen, but there are no well-designed studies on its use in transgender women. Potential adverse effects include depression, weight gain, and an increase in lipids.
The speed and extent of hormonal changes vary from person to person. Some body features may change almost immediately, while others may take years to develop.





How much estrogen is needed to transition?
Estrogen. Estradiol is preferred, as it most closely resembles the hormone produced by the ovaries. It is prescribed in a similar way to hormone replacement therapy for postmenopausal women, but with slightly higher doses. The dose of estradiol valerate tablets starts at 2–4 mg daily, increasing up to 8 mg.


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The cost of estrogen varies widely depending on the type of estrogen, the delivery system, and whether you have insurance. Here are some examples of estrogen costs:
Generic estradiol tablets: The most affordable type of estrogen, costing around $20 or less per month with a GoodRx coupon
Vaginal ring: A 90-day vaginal ring can cost more than $800
Estrogen pills: Can cost $45–$90 every 90 days
Estrogen patches: Can cost $175–$446 every 90 days
Estradiol injections: Can cost $214–$372 every 90 days
Pellet therapy: Costs between $1,050–$1,400 for women and $1,400–$2,100 for men
Creams, gels, and patches: Cost around $60–$360 for an insured person and $120–$1,020 for those who are uninsured
Most insurance plans cover some form of estradiol, but you may still have high out-of-pocket costs. You can check online for manufacturer savings, such as patient assistance programs and copay discount cards. You can also talk to your healthcare provider about less costly alternatives and medication samples.


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Is hormone blood test expensive?
The least expensive kits cost as little as $45, while the most comprehensive kits, which test for more than 10 hormones, cost around $200. If your insurance company covers home testing kits, you may have to pay a copay or meet your deductible, so the cost may vary, depending on the terms of your health plan.


Posted Sat Oct 19, 2024 1:54 pm

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